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See Latest ArticlesTopoisomerase I but not thymidylate synthase is associated with improved outcome in patients with resected colorectal cancer treated with irinotecan containing adjuvant chemotherapy
BMC Cancer, 09/30/09
Kostopoulos I et al. – Patients with resected CRC expressing Topo I seem to benefit from irinotecan-containing adjuvant chemotherapy.
Methods- Archival paraffin-embedded tumor tissues were used for immunohistochemical detection of TS and Topo I
- Immunohistochemistry was performed on tissue microarray slides using monoclonal antibodies against TS and Topo I
- A cohort of 498 patients with a median age of 61 years and Dukes' stage B (49%) and C (51%) fulfilled the criteria of the study
- All patients received adjuvant 5-FU-based chemotherapy, 38% irinotecan-containing
- Positive TS and Topo I expression was found in 43% and 48% of cases, respectively
- Five-year OS was 74% and DFS was 68%
- In univariate analysis no association of TS and Topo I expression with OS and DFS was identified
- In multivariate analysis however, Topo I expression was associated with a reduced risk of death
- In the irinotecan-treated subgroup, those patients who expressed Topo I had a better OS
Today in Basic Science/Genetics...keeping you current
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Serum calcium levels are elevated among women with untreated postmenopausal breast cancer
Cancer Causes and Control, 11/03/09
Circulating tumour cells early predict progression-free and overall survival in advanced colorectal cancer patients treated with chemotherapy and targeted agents
Annals of Oncology, 11/02/09
Evaluating the combined effect of comorbidity and prostate-specific antigen kinetics on the risk of death in men after prostate-specific antigen recurrence
Journal of Clinical Oncology, 11/02/09
Today in Colorectal Cancer/Polyps...keeping you current
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Localized resection for colon cancer
Surgical Oncology, 11/04/09
Effect of bevacizumab in older patients with metastatic colorectal cancer: Pooled analysis of four randomized studies
Journal of Cancer Research & Clinical Oncology, 11/17/09
A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma
American Journal of Clinical Nutrition, 10/29/09
Today in Pharmacology/Therapy...keeping you current
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Activity of fulvestrant in HER2-overexpressing advanced breast cancer
Annals of Oncology, 11/06/09
Randomized phase II study of gemcitabine administered at a fixed dose rate or in combination with cisplatin, docetaxel, or irinotecan in patients with metastatic pancreatic cancer
Journal of Clinical Oncology, 11/02/09
Comparison of neurocognitive functioning in children previously randomly assigned to intrathecal methotrexate compared with triple intrathecal therapy for the treatment of childhood acute lymphoblastic leukemia
Journal of Clinical Oncology, 11/09/09
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