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The accuracy of frozen section analysis in ultrasound- guided core needle biopsy of breast lesions
BMC Cancer, 09/29/09

Brunner AH et al. – The frozen section analysis of suspect breast lesions performed by CNB displays good sensitivity/specificity characteristics. Immediate investigations of CNB is an accurate diagnostic tool and an important step in reducing psychological strain by minimizing the period of uncertainty in patients with breast tumor.

Methods

Retrospective analysis data of 120 consecutive handheld ultrasound- guided 14- gauge automated core needle biopsies (CNB) in 109 consecutive patients with breast lesions between 2006 and 2007 were evaluated

Results

120 CNB were performed
59/120 (49.2%) cases we compared histological diagnosis on frozen sections with those on paraffin sections of CNB and finally with the result of open biopsy
Of the cases 42/59 (71.2 %) proved to be malignant and 17/59 (28.8%) to be benign in definitive histology
2/59 (3.3%) biopsies had a false negative frozen section result
No false positive results of the intraoperative frozen section analysis were obtained, resulting in a sensitivity, specificity and positive predicting value (PPV) and negative predicting value (NPV) of 95%, 100%, 100% and 90%, respectively
Histological and morphobiological parameters did not show up relevance for correct frozen section analysis
In cases of malignancy time between diagnosis and definitive treatment could not be reduced due to frozen section analysis

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