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See Latest ArticlesBcl-xL and MCL-1 constitute pertinent targets in ovarian carcinoma and their concomitant inhibition is sufficient to induce apoptosis
International Journal of Cancer, 09/29/09
Brotin E et al. – In presence of a low concentration of cisplatin, the concomitant down–regulation of Bcl–xL and MCL–1 allowed a complete annihilation of tumour cells population thus avoiding subsequent recurrence in vitro in cell lines highly refractory to any type of conventional chemotherapy. Therefore, Bcl–xL and MCL–1 targeted strategies could constitute an efficient therapeutic tool for the treatment of chemoresistant ovarian carcinoma, in association with conventional chemotherapy.
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Today in Basic Science/Genetics...keeping you current
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Activating Peroxisome Proliferator-Activated Receptor gamma Mutant Promotes Tumor Growth In vivo by Enhancing Angiogenesis
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Today in Gynecologic Oncology...keeping you current
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Epithelial-to-Mesenchymal Transition and Ovarian Tumor Progression Induced by Tissue Transglutaminase
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