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See Latest ArticlesHigh factor VIII levels independently predict venous thromboembolism in cancer patients. The Cancer and Thrombosis Study
Arteriosclerosis, Thrombosis, and Vascular Biology, 09/30/09
Vormittag R et al. – FVIII is independently associated with an increased risk of VTE in cancer patients. The association between FVIII and VTE risk declines with increasing age.
Methods- The prospective observational Cancer and Thrombosis Study includes patients with newly diagnosed cancer or disease progression, study end point is symptomatic VTE
- Data on 840 patients (median age: 62 years, 25th to 75th percentile 53 to 68, 378 women) were available for analyses, of these 111 patients had hematologic malignancies and 729 solid cancer
- During a median observation time of 495 days 62 events occurred
- Cumulative probability of VTE after 6 months was 14% in patients with elevated FVIII-levels and 4% in those with normal levels
- The association was strongest in younger patients, whereas in 40-year-old patients a 2-fold VTE risk per factor VIII increase of 20% was observed; this association was still present but attenuated in older patients
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