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Autocrine Loop between Vascular Endothelial Growth Factor (VEGF)-C and VEGF Receptor-3 Positively Regulates Tumor-Associated Lymphangiogenesis in Oral Squamoid Cancer Cells
American Journal of Pathology, 09/29/09
Matsuura M et al. – The significant suppression of VEGF–C and VEGF–A expression was evident in dn–SAS cells or wild–type SAS cells treated with either the FLT–4 kinase inhibitor MAZ51 or the inhibitor of FLT–4–related signals. These findings together suggested that the VEGF–C/FLT–4 autocrine loop in tumor cells was a potential enhancer system to promote cancer progression, and FLT–4 in tumor tissue might become an effective target for cancer therapy.
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Today in Basic Science/Genetics...keeping you current
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Gene-expression-based analysis of local and metastatic neuroblastoma variants reveals a set of genes associated with tumor progression in neuroblastoma patients
International Journal of Cancer, 12/15/09
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Today in Head and Neck...keeping you current
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Nuclear receptors in head and neck cancer: current knowledge and perspectives
International Journal of Cancer, 12/15/09
MicroRNA expression in head and neck cancer associates with alcohol consumption and survival
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Genetic polymorphisms in the PTPN13 gene and risk of squamous cell carcinoma of head and neck
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