Oncology Medical News about thrombomodulin activation

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Molecular basis of thrombomodulin activation of slow thrombin
Journal of Thrombosis and Haemostasis, 09/25/09

Adams TE et al. – These data show that TM binding alters the conformation of thrombin in a similar manner as Na+ coordination, resulting in an ordering of the Na+ binding loop and an opening of the adjacent S1 pocket. The authors conclude that other, more subtle subsite changes are unlikely to influence thrombin specificity toward macromolecular substrates.

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