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Diagnosis of mild platelet function disorders. Reliability and usefulness of light transmission platelet aggregation and serotonin secretion assays
British Journal of Haematology, 10/05/09

Quiroga T et al. – Normal PA with adrenaline and low ADP concentration robustly predict a normal PA. Simultaneous PA/PS assays enable the diagnosis of isolated PS defects. This study confirmed that hereditary PA–PS defects are highly prevalent.

Exclusive Author Commentary
Diego Mezzano, 10/07/09

Standardized platelet aggregation and serotonin secretion assays are highly consistent with more than 90% reproducibility, both in healthy controls and patient populations. These are specially suited for diagnosis of mild platelet function defects. This study found that a normal platelet aggregation using 10 micromolar adrenaline is strongly predictive of a normal platelet aggregation, e.g., 93% of the patients with hereditary mucous and skin bleeding who have a maximal percent of aggregation of 42% or more with adrenaline end up with an overall normal platelet aggregation. Furthermore, this study found that up to 14.3% of the patients may have an abnormal platelet serotonin secretion with normal platelet aggregation, emphasizing the need to perform both studies simultaneously.

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