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See Latest ArticlesFLT3-ITD expression levels and their effect on STAT5 in AML with and without NPM mutations
British Journal of Haematology, 10/06/09
Seedhouse CH et al. – FLT3–internal tandem duplication (ITD) mutations are heterogeneous with regards to length and proportion of DNA harbouring the mutation and the expression level of FLT3 also varies widely, however very little is known about the biological effects of these variables. Phospho–STAT5 levels were reduced in the FLT3–ITD/NPMc+ group (P = 0·04) suggesting that NPMc+ may oppose the FLT3–ITD–dependent activation of STAT5.
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Today in Basic Science/Genetics...keeping you current
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Endocellular polyamine availability modulates epithelial-to-mesenchymal transition and unfolded protein response in MDCK cells
Laboratory Investigation, 03/19/10
Functional significance of the two ACOX1 isoforms and their crosstalks with PPAR[alpha] and RXR[alpha]
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Protein pathway biomarker analysis of human cancer reveals requirement for upfront cellular-enrichment processing
Laboratory Investigation, 03/19/10
Today in Leukemia/Lymphoma...keeping you current
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Final analysis of the UKLG LY02 trial comparing 6–8 cycles of CHOP with 3 cycles of CHOP followed by a BEAM autograft in patients <65 years with poor prognosis histologically aggressive NHL
British Journal of Haematology, 03/19/10
Review of phenotypic markers used in flow cytometric analysis of MGUS and MM, and applicability of flow cytometry in other plasma cell disorders
British Journal of Haematology, 03/19/10
High immunohistochemical expression of p-AKT predicts inferior survival in patients with diffuse large B-cell lymphoma treated with immunochemotherapy
British Journal of Haematology, 03/19/10
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