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See Latest ArticlesPolymorphisms in telomere maintenance genes and risk of lung cancer
Cancer Epidemiology, Biomarkers & Prevention, 09/30/09
Choi JE et al. – Genetic variants in the TERT and TNKS1 genes contribute to genetic susceptibility to lung cancer.
Methods- We captured 35 polymorphisms in the genes and determined their frequencies in 27 healthy Koreans
- Ten haplotype-tagging polymorphisms were examined in a case-control study that consisted of 720 lung cancer patients and 720 healthy controls
- The TERT rs2735940 g.C > T and rs2736098 g.G > A, and TNKS1 rs6985140 g.A > G were significantly associated with the risk of lung cancer
- In the haplotype analysis, the TERT rs2735940T/rs2736098A haplotype (ht4) was associated with a significantly increased risk of lung cancer compared with the rs2735940C/rs2736098G haplotype
- When the TERT ht4 and TNKS1 rs6985140G as risk alleles, the risk of lung cancer increased in a dose-dependent manner as the number of risk alleles increased
- Subjects with two to four risk alleles were at a significantly increased risk of lung cancer compared with subjects with zero risk allele
Today in Basic Science/Genetics...keeping you current
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Target genes suitable for silencing approaches and protein product interference in ovarian epithelial cancer
Cancer Treatment Reviews, 12/04/09
Dysregulation of Platelet-Derived Growth Factor beta-Receptor Expression by deltaNp73 in Neuroblastoma
Molecular Cancer Research, 12/04/09
Tissue transglutaminase 2 as a biomarker of cervical intraepithelial neoplasia (CIN) and its relationship to p16INK4A and nuclear factor kappaB expression
Virchows Archiv, 12/04/09
Today in Lung/Thoracic Oncology...keeping you current
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Phase I Study of Accelerated Conformal Radiotherapy for Stage I Non-Small-Cell Lung Cancer in Patients With Pulmonary Dysfunction: CALGB 39904
Journal of Clinical Oncology, 12/04/09
Management of lung nodules detected by volume CT scanning
New England Journal of Medicine, 12/03/09
Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Cancer Causes and Control, 12/03/09
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