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See Latest ArticlesChromogranin A (CgA) serum level as a marker of progression in hepatocellular carcinoma (HCC) of elderly patients
Archives of Gerontology and Geriatrics, 09/24/09
Malaguarnera M et al. – CgA was significantly higher in the patients affected by HCC as compared with those affected by either hepatitis or cirrhosis. The authors also observed significant differences, comparing CgA serum levels in the tumor classes T1–T4: T1 vs. T2, T1 vs. T3, T1 vs. T4, T2 vs. T3, T2 vs. T4 and T3 vs. T4. CgA levels were significantly higher in poorly differentiated HCC vs. well differentiated and medium differentiated ones. Also the comparison between Child–Pugh degree A and C showed a significant difference in CgA levels. Thereby, patients with higher CgA level had poor survival and showed poor prognosis, compared to those with lower CgA level, i.e., the CgA is useful in monitoring progression of disease and may assist as a prognostic indicator.
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