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Direct cancer–stromal interaction increases fibroblast proliferation and enhances invasive properties of scirrhous-type gastric carcinoma cells
British Journal of Cancer, 09/25/09
Semba S et al. – Scirrhous–type gastric carcinoma (SGC) exhibits an extensive submucosal fibrosis and extremely poor patient prognosis. Direct interaction between SGC cells and gastric fibroblasts establishes the tumour microenvironment and reinforces the aggressiveness of SGC.
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