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Effects of tamoxifen and raloxifene on memory and other cognitive abilities: cognition in the study of tamoxifen and raloxifene
Journal of Clinical Oncology, 09/23/09

Legault Cet al. – Tamoxifen and raloxifene are associated with similar patterns of cognitive function in postmenopausal women at increased risk of breast cancer. Future comparisons between these findings and patterns of cognitive function in hormone therapy and placebo groups in WHISCA should provide additional insights into the effects of tamoxifen and raloxifene on cognitive function in older women.

Methods

Randomized clinical trial of tamoxifen 20 mg/d or raloxifene 60 mg/d in healthy postmenopausal women at increased risk of breast cancer
1,498 women were randomly assigned in STAR were age 65 years and older, not diagnosed with dementia, and enrolled onto the Cognition in the Study of Tamoxifen and Raloxifene (Co-STAR) trial
Began 18 months after STAR enrollment started
Analyses conducted on all participants and 273 women who completed first cognitive battery before they started taking their medications

Results

No significant differences in adjusted mean cognitive scores between the two treatment groups across visits
Significant time effects across the three visits for some of the cognitive measures
Similar results obtained for subset of women with true baseline measures

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