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Primary testicular diffuse large B-cell lymphoma: a population-based study on the incidence, natural history, and survival comparison with primary nodal counterpart before and after the introduction of rituximab
Journal of Clinical Oncology, 09/28/09

Gundrum JD et al. – The incidence of testicular DLBCL is increasing. Compared with nodal DLBCL, testicular DLBCL patients have a better overall prognosis but are at higher risk of late disease-related deaths. The introduction of rituximab in clinical practice does not seem to improve their early outcome.

Methods

Surveillance, Epidemiology, and End Results database reviewed to identify patients diagnosed between 1980 and 2005
To study potential impact of introduction of rituximab on survival, year 2000 was used as cutoff point

Results

769 patients with testicular DLBCL identified
Median age at diagnosis 68.0 years
Incidence of DLBCL increased over time, with highest rate among whites (twice that of blacks)
Median OS for the whole group was 4.6 years, whereas the DSS rates at 3, 5, and 15 years were 71.5%, 62.4%, and 43.0%, respectively
Independent predictors of worse DSS were older age, diagnosis before 1986, advanced stage, left testicular involvement, and not having surgery and radiation
Testicular primary was an independent predictor of better OS and DSS
DSS did not improve in patients with testicular DLBCL diagnosed after 2000

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