Oncology Medical News about thrombocythemia

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JAK2V617F allele burden discriminates essential thrombocythemia from a subset of prefibrotic-stage primary myelofibrosis
Experimental Hematology, 09/22/09

Hussein K et al. – Histopathological categories ET and prefibrotic PMF correlate with significant differences in mutant allelic burden of JAK2V617F, but not of MPLW515L which, by contrast to JAK2V617F, shows a higher percentage of mutated alleles in fibrotic than in prefibrotic cases. Thus, for Ph? MPN in which ET and prefibrotic PMF represent the most probable diagnoses, a JAK2V617F allele burden >50% favors a diagnosis of prefibrotic PMF.

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A latent form of essential thrombocythemia presenting as portal cavernoma
World Journal of Gastroenterology, 11/18/09 Relevance Score: 87%%

The influence of low-dose aspirin and hydroxyurea on platelet-leukocyte interactions in patients with essential thrombocythemia
Blood Coagulation & Fibrinolysis, 11/03/09 Relevance Score: 85%%

MicroRNA expression profiling of megakaryocytes in primary myelofibrosis and essential thrombocythemia
Platelets, 10/02/09 Relevance Score: 85%%

Src tyrosine kinase pre-activation is associated with platelet hypersensitivity in essential thrombocythemia and polycythemia vera
Blood, 11/25/09 Relevance Score: 84%%

The JAK2 46/1 haplotype confers susceptibility to essential thrombocythemia regardless of JAK2V617F mutational status—clinical correlates in a study of 226 consecutive patients
Leukemia, 10/27/09 Relevance Score: 84%%