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See Latest ArticlesSerum CA 125 expression as a tumor marker for diagnosis and monitoring the clinical course of epithelioid sarcoma
Journal of Cancer Research & Clinical Oncology, 09/28/09
Hoshino M et al. – This study concluded that epithelioid sarcoma cells produce and secrete CA 125 into the blood serum and that the elevation of serum CA 125 correlates with disease progression. Therefore, measuring the serum CA 125 level should provide an useful index for diagnosing and monitoring the course of epithelioid sarcoma.
Methods- Serum CA 125 levels of seven epithelioid sarcoma patients examined at multiple time points
- Expression of the MUC16 gene that encodes CA 125 sequence was examined using RT-PCR methods in three epithelioid sarcoma cell lines, FU-EPS-1, SFT-8606 and NEPS
- CA 125 protein in each cell lysate examined by Western blot using anti-CA 125 clone OC125 antibody
- Concentration of CA 125 in conditioned medium of each cell line measured
- In five of seven epithelioid sarcoma patients, CA 125 levels reflected regression and progression of disease.
- CA 125 concentrations in conditioned medium of FU-EPS-1, SFT-8606 and NEPS cells were 259, 252, and 6 U/ml, respectively
- Strong expression of MUC16 mRNA shown in FU-EPS-1 and SFT-8606 cells: correspondingly
- Thick band was observed by Western blot analysis in only FU-EPS-1 and SFT-8606 cells
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Today in Soft Tissue/Sarcoma...keeping you current
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