Oncology Medical News about cholangiocarcinoma

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CpG island hypermethylation and repetitive DNA hypomethylation in premalignant lesion of extrahepatic cholangiocarcinoma
Virchows Archiv, 09/23/09

Kim B–H et al. – Most of cancer–specific CpG island hypermethylation occur in the stage of BilIN and that CpG island hypermethylation seems to occur earlier than repetitive DNA element hypomethylation.

Exclusive Author Commentary
Gyeong Hoon Kang, 09/23/09

Our study has addressed that CpG island hypermethylation occurs early in the multistep carcinogenesis like other tissue types of carcinomas and most of cancer-specific hypermethylation occurs in biliary intraepithelial neoplasia stage. With this information, bile-based methylation detection is worth of being tried to detect extrahepatic cholangiocarcinoma and its premalignant lesion.

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One hundred seven consecutive surgical resections for hilar cholangiocarcinoma of Bismuth types II, III, IV between 2001 and 2008
Journal of Hepato-Biliary-Pancreatic Surgery, 11/25/09 Relevance Score: 90%

Disease recurrence patterns after R0 resection of hilar cholangiocarcinoma
British Journal of Surgery, 12/01/09 Relevance Score: 87%

Surgical Management of Infrahilar/Suprapancreatic Cholangiocarcinoma: an Analysis of the Surgical Procedures, Surgical Margins, and Survivals of 77 Patients
Journal of Gastrointestinal Surgery, 11/13/09 Relevance Score: 87%

L1 Cell Adhesion Molecule Is a Novel Independent Poor Prognostic Factor of Extrahepatic Cholangiocarcinoma
Clinical Cancer Research, 11/20/09 Relevance Score: 85%

Comorbidity negatively influences prognosis in patients with extrahepatic cholangiocarcinoma
World Journal of Gastroenterology, 11/13/09 Relevance Score: 85%