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Prognostic factors in oropharyngeal cancer - analysis of 627 cases receiving definitive radiotherapy
Acta Oncologica, 09/25/09

Agarwal JP et al. – Oropharyngeal cancers in those without a history of tobacco abuse may be biologically different and more amenable to cure with radiotherapy.

• The records of 627 patients with oropharyngeal cancer treated with radical radiotherapy with conventional techniques were analyzed

• History of tobacco abuse was present in 80.5%
• Radical radiotherapy alone was the treatment modality for 71.2% and concomitant or neoadjuvant chemotherapy was used in 28.8%
• The 3-year local control (LC), loco-regional control (LRC), DFS and OS was 49%, 40.6%, 38.9% and 36.1% respectively
• The 3-year DFS rates were 80.3% for stage I, 65.8% for stage II, 46.1% for stage III and 25.2% for stage IV disease
• Prior history of tobacco abuse was an independent prognostic factor for both DFS and LRC
• Karnofsky Performance Score (KPS) < 80, higher nodal stage, lower total radiotherapy dose (<66 Gy) in those receiving > 60 Gy, and overall treatment time > 50 days were other independent prognostic factors for inferior DFS and LRC
• KPS < 80, higher T stage, higher nodal stage, RT dose < 66 Gy and longer overall treatment time (>50 days) were independent prognostic factors for poorer local control

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