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See Latest ArticlesAssociation of a dominantly inherited hyperphosphorylated paraprotein target with sporadic and familial multiple myeloma and monoclonal gammopathy of undetermined significance: a case—control study
The Lancet Oncology - Online First, 09/23/09
Grass S et al. – Familial MGUS and multiple myeloma were associated with a dominant inheritance of hyperphosphorylated paratarg–7, enabling family members at increased risk for MGUS or multiple myeloma to be identified. That only patients with MGUS or multiple myeloma who are carriers of hyperphosphorylated paratarg–7 had a paratarg–7–specific paraprotein suggests that the hyperphosphorylation of paratarg–7 induces auto–immunity and is involved in the pathogenesis of MGUS and multiple myeloma; for example, by chronic antigenic stimulation.
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