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Risk of bleeding with vascular endothelial growth factor receptor tyrosine-kinase inhibitors sunitinib and sorafenib: a systematic review and meta-analysis of clinical trials
The Lancet Oncology - Online First, 09/25/09
Je Y et al. – Sunitinib and sorafenib are oral vascular endothelial growth factor receptor (VEGFR) tyrosine–kinase inhibitors used in various cancers. Bleeding has been described with these agents, although the overall risk remains unclear. Treatment with the VEGFR tyrosine–kinase inhibitors sunitinib and sorafenib is associated with a significant increase in risk of bleeding.
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