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An onco-informatics database for anticancer drug interactions with complementary and alternative medicines used in cancer treatment and supportive care: an overview of the OncoRx project
Supportive Care in Cancer, 09/23/09
Yap KYL et al. – OncoRx is an oncology database which detects ACD interactions. It is currently able to detect interactions with CAMs.
Methods- Information regarding ACDs, CAMs, and drug interactions were collated
- Input into a modified web server with a database engine and a programming interface using a combination of software and programming scripts
- OncoRx currently contains a total of 117 ACDs and 166 CAMs
- Users able to search for interactions based on various CAM uses: cancer treatment or prevention, immune-system-related, alopecia, nausea, and vomiting, peripheral neuropathy and pain, inflammation, fatigue, and non-cancer related
- Pharmacokinetic data on ACDs and CAMs, characteristics of CAMs based on TCM principles, and drug interaction parameters such as effects, mechanisms, evidences, and proposed management plans, are shown in search results
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Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway
Cancer Letters, 12/04/09
Efficacy of Goshajinkigan for Peripheral Neurotoxicity of Oxaliplatin in Patients with Advanced or Recurrent Colorectal Cancer
Evidence-based Complementary and Alternative Medicine , 12/02/09
Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3
Carcinogenesis, 12/01/09
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