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Zhang X et al. – N3–o–toluyl–fluorouracil (TFU), the prodrug of 5–fluorouracil (5–FU), is the metabolite of N1–acetyl–N3–o–toluyl–fluorouracil (atofluding). The results demonstrate that TFU is a promising prodrug of 5–FU for cancer treatment via sustained release of 5–FU in liver.


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