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OH-2, a hyperdiploid myeloma cell line without an IGH translocation, has a complex translocation juxtaposing MYC near MAFB and the IGK locus
Leukemia Research, 09/22/09
Vatsveen TK et al. – Multiple myeloma can be classified into hyperdiploid (HRD) (with 48–74 chromosomes) and non–hyperdiploid tumors (usually with immunoglobulin heavy chain translocations. OH–2 provides a unique example of an HMCL and the corresponding primary tumor that are shown to share the same HRD genotype.
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Today in Basic Science/Genetics...keeping you current
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