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See Latest ArticlesComparative analysis of annexin-1 in neuroepithelial tumors shows altered expression with the grade of malignancy but is not associated with survival
Modern Pathology, 09/25/09
Schittenhelm J et al. – Annexin-1 upregulation in astrocytomas may contribute to tumor progression and its expression profile is similar to its substrate, EGFR, suggesting a possible regulation thereof.
Methods- Annexin-1 expression was studied in 394 glial neoplasms of all grades of malignancy and 81 normal brain samples by immunohistochemistry using tissue microarrays
- The results were validated using western blot and reverse transcription-PCR (RT-PCR)
- Ependymomas and astrocytomas showed significantly higher mean annexin-1 expression levels in the cytoplasm compared with oligodendrogliomas
- In addition, nuclear staining of annexin-1 in oligodendroglial tumor cells was significantly reduced, which may be used as a diagnostic tool for differentiating between astrocytomas and oligodendrogliomas
- Although annexin-1 expression in ependymomas decreased with the grade of malignancy, diffuse astrocytomas showed a significant increase in cytoplasmic annexin-1-positive tumor cells; however, survival analysis showed that the expression of annexin-1 is not associated with patient survival
- Similar to the EGFR amplification profile, primary glioblastomas had a higher annexin-1 expression level compared with secondary glioblastomas
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