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See Latest ArticlesBiological indicators of prognosis in Ewings sarcoma: An emerging role for lectin galactoside-binding soluble 3 binding protein (LGALS3BP)
International Journal of Cancer, 09/21/09
Zambelli D et al. – LGALS3BP as a novel reliable indicator of prognosis.
Methods- Functional annotation of differentially regulated genes revealed 3 major networks related to cell cycle, cell-to-cell interactions and cellular development; the prognostic impact of 8 genes, representative of these 3 networks, was validated in 56 EWS patients
- High mRNA expression levels of HINT1, IFITM2, LGALS3BP, STOML2 and c-MYC were associated with reduced risk to death and lower risk to develop metastasis
- LGALS3BP, a matricellular protein with a role in tumor progression and metastasis, was the most important predictor of event-free survival and overall survival
- The association between LGALS3BP and prognosis was confirmed at protein level, when expression of the molecule was determined in tumor tissues but not in serum, indicating a role for the protein at local tumor microenvironment
- Engineered enhancement of LGALS3BP expression in EWS cells resulted in inhibition of anchorage independent cell growth and reduction of cell migration and metastasis
- Silencing of LGALS3BP expression reverted cell behavior with respect to in vitro parameters, thus providing further functional validation of genetic data obtained in clinical samples
Today in Basic Science/Genetics...keeping you current
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Gene-expression-based analysis of local and metastatic neuroblastoma variants reveals a set of genes associated with tumor progression in neuroblastoma patients
International Journal of Cancer, 12/15/09
BEX2 regulates mitochondrial apoptosis and G1 cell cycle in breast cancer
International Journal of Cancer, 12/15/09
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International Journal of Cancer, 12/15/09
Today in Soft Tissue/Sarcoma...keeping you current
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Aggressive fibromatosis in children and adolescents
Cancer, 12/15/09
Immunoprofile of mesenchymal chondrosarcoma: aberrant desmin and EMA expression, retention of INI1, and negative estrogen receptor in 22 female-predominant central nervous system and musculoskeletal cases
Annals of Diagnostic Pathology, 12/12/09
Birth characteristics and the risk of childhood rhabdomyosarcoma based on histological subtype
British Journal of Cancer, 12/11/09
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