Oncology Medical News about somaatostatin receptor receptor tissue;lung neuroendocrine tunors

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Somatostatin receptor tissue distribution in lung neuroendocrine tumours: a clinicopathologic and immunohistochemical study of 218 ‘clinically aggressive’ cases
Annals of Oncology, 09/18/09

Righi L et al. – The immunohistochemical determination of SSTRs, with special reference to low-grade/intermediate-grade tumours, may assist the clinical approach with somatostatin analogue-based diagnostic and therapeutic procedures in clinically aggressive pulmonary NETs.

Methods

A series of 218 lung NETs [24 metastatic typical carcinoids (TCs), 73 atypical carcinoids (ACs), 60 LCNECs and 61 surgically resected small-cell lung carcinomas] were investigated for SSTR types 2A and 3 tissue distribution using immunohistochemistry, in correlation with clinicopathologic parameters, outcome, scintigraphy and treatment

Results

SSTRs were heterogeneously distributed with a significant progressive decrease from low- to high-grade forms
SSTR type 2A was strikingly overexpressed in metastatic TCs as compared with ACs and clinically benign TCs
SSTR tissue immunolocalization correlated with octreotide scintigraphy in 20 of 28 cases

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