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Down-regulation of Suppressor of Cytokine Signaling-3 Causes Prostate Cancer Cell Death through Activation of the Extrinsic and Intrinsic Apoptosis Pathways
Cancer Research, 09/18/09
Puhr M et al. – SOCS–3 is an important protein in the survival machinery in prostate cancer and is overexpressed in castration–resistant tumors. SOCS–3 knockdown results in an increase of cell death via activation of the extrinsic and intrinsic apoptosis pathways.
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Target genes suitable for silencing approaches and protein product interference in ovarian epithelial cancer
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