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See Latest ArticlesGenetic Alterations in the Phosphoinositide 3-Kinase/Akt Signaling Pathway Confer Sensitivity of Thyroid Cancer Cells to Therapeutic Targeting of Akt and Mammalian Target of Rapamycin
Cancer Research, 09/18/09
Liu D et al. – This work for the first time shows that genetic alterations in the PI3K/Akt pathway confer thyroid cancer cells addiction to this pathway and their sensitivity to inhibition by targeting Akt and mTOR. This genotype–based targeting of the PI3K/Akt pathway using Akt and mTOR inhibitors may offer an effective therapeutic strategy for thyroid cancer and warrants further studies.
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Today in Basic Science/Genetics...keeping you current
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Today in Endocrine Oncology...keeping you current
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Controversy surrounding the role for routine central lymph node dissection for differentiated thyroid cancer
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