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See Latest ArticlesInactivation of the Carney Complex Gene 1 (Protein Kinase A Regulatory Subunit 1A) Inhibits SMAD3 Expression and TGFbeta-Stimulated Apoptosis in Adrenocortical Cells
Cancer Research, 09/17/09
Ragazzon B et al. – PRKAR1A silencing decreased the percentage of apoptotic cells and the cleavage of apoptosis mediators [caspase–3, poly(ADP–ribose) polymerase, and lamin A/C]. Inactivating mutations of PRKAR1A observed in adrenocortical tumors alter SMAD3, leading to resistance to TGFbeta–induced apoptosis. This cross–talk between the PKA and the TGFbeta signaling pathways reveals a new mechanism of endocrine tumorigenesis.
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Today in Basic Science/Genetics...keeping you current
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Activating Peroxisome Proliferator-Activated Receptor gamma Mutant Promotes Tumor Growth In vivo by Enhancing Angiogenesis
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Today in Endocrine Oncology...keeping you current
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Diagnostic Accuracy of rhTSH Test with Neck Ultrasonography in Differentiated Thyroid Cancer Follow-up
Experimental and Clinical Endocrinology & Diabetes, 12/19/09
Fas Ligand (FasL, Apo-1L/CD95L) Expression and Clinical Outcome in Papillary Microcarcinoma and Papillary Thyroid Carcinomas with Diameter Smaller than 1.5 Centimeters
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