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KDR Activating Mutations in Human Angiosarcomas Are Sensitive to Specific Kinase Inhibitors
Cancer Research, 09/17/09
Antonescu CR et al. – Transient transfection of KDR mutants into COS–7 cells showed ligand–independent activation of the kinase, which was inhibited by specific KDR inhibitors. These data provide a basis for the activity of vascular endothelial growth factor receptor–directed therapy in the treatment of primary and radiation–induced AS.
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Today in Basic Science/Genetics...keeping you current
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Expression of p16 in benign and malignant cystic squamous lesions of the neck
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