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Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Recommendations on the use of 18F-FDG PET in oncology

3. Taxane-based combinations as adjuvant chemotherapy of early breast cancer: a meta-analysis of randomized trials

4. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer

5. Sentinel node biopsy is important in mastectomy for ductal carcinoma in situ

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Limitations of PET/CT in determining need for neck dissection after primary chemoradiation for advanced head and neck squamous cell carcinoma
Journal for Oto-Rhino-Laryngology, 09/17/09

Lyford-Pike S et al. – PET/CT is neither highly sensitive nor highly specific for identifying residual nodal metastases after CRT for advanced-stage HNSCC.

Methods

Retrospective study
38 patients received primary CRT for HNSCC with N2 or greater disease, PET/CT after treatment and neck dissection
PET/CT results were correlated with pathology results from neck dissection specimens for each respective side

Results

46 neck regions were analyzed
9 were determined to have either PET/CT result reports (n = 5) or pathology reports (n = 4) that were indeterminate
PET/CT demonstrated a sensitivity and specificity of 57.1% and 73.9%, respectively, an accuracy of 67.5%, a positive predictive value of 57.1% and a negative predictive value of 73.9% when compared to the final pathology

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