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See Latest ArticlesAbsence of VHL gene alteration and high VEGF expression are associated with tumour aggressiveness and poor survival of renal-cell carcinoma
British Journal of Cancer, 09/17/09
Patard J-J et al. – Median PFS and CCRCC-specific survival were significantly reduced in patients with wild-type VHL or altered VHL and high VEGF expression, which, therefore, represent two markers of tumour aggressiveness in CCRCC.
Methods- 102 patients with CCRCC were prospectively analysed
- Alterations in VHL were determined by sequencing, Multiplex Ligation-dependent Probe Amplification (MLPA) and methylation-specific MLPA
- Expression of pVHL and VEGF was determined by immunohistochemistry
- Plasma VEGF was measured by ELISA
- VHL mutation, deletion and promoter methylation were identified in 70, 76 and 14 cases, respectively
- At least one VHL-gene alteration occurred in 91 cases (89.2%)
- Both VEGF tumour and plasma expression appeared to be decreased in case of VHL alteration
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