Oncology Medical News

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Recommendations on the use of 18F-FDG PET in oncology

3. Taxane-based combinations as adjuvant chemotherapy of early breast cancer: a meta-analysis of randomized trials

4. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer

5. Sentinel node biopsy is important in mastectomy for ductal carcinoma in situ

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Sonographic and electrodiagnostic evaluations in patients with aromatase inhibitor-related arthralgia
Journal of Clinical Oncology, 09/15/09

Dizdar O et al. – Patients with AI-related arthralgia often show tenosynovial changes suggesting tenosynovitis, exerting local problems but lacking a systemic inflammatory component. These findings of increased CTS frequency also support this hypothesis.

Methods

Postmenopausal patients with stage I to III breast cancer who were taking adjuvant AIs were enrolled (n = 92)
Patients not receiving hormone treatment were included as a control group (n = 28)
Musculoskeletal sonography and EMG applied to the patients and controls along with markers of autoimmunity.

Results

30 (32.6%) reported to have AI-related new-onset or worsening arthralgia
Most commonly affected joints were knee (70%), wrist (70%), and small joints of the hand (63%)
Patients taking AIs showed increased tendon thicknesses compared with those who never received AIs
AI-related arthralgia had higher rates of effusion in hand joints/tendons than those without arthralgia
More AI-related arthralgia had EMG findings consistent with carpal tunnel syndrome (CTS) than without arthralgia
No significant difference in ESR
No significant difference in C-reactive protein
No significant difference in antinuclear antibody, antidouble stranded DNA antibody, rheumatoid factor
No significant difference in cyclic citrullinated peptide levels between patients and controls or between those with and without arthralgia

<< Previous
Aromatase inhibitor-induced carpal tunnel syndrome: Results from...

Next >>
A phase I/II study of the safety and efficacy of the addition of...