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Aromatase inhibitor-induced carpal tunnel syndrome: Results from the ATAC Trial
Journal of Clinical Oncology, 09/15/09

Sestak I et al. – Although the use of anastrozole is associated with a greater incidence of CTS, it is rare, and most cases were of mild to moderate intensity and short duration. CTS has little impact on the overall risk-to-benefit ratio for the use of anastrozole in postmenopausal women with early breast cancer.

Methods

Analyses were based on the 100-month median follow-up data in postmenopausal women in the two monotherapy arms
Investigated the natural history of patients who presented with CTS during adjuvant treatment for breast cancer and relative importance of range of known risk factors for CTS

Results

After 100 months of follow-up, 80 cases of CTS reported in anastrozole arm, compared with 23 cases in the tamoxifen arm
Majority of CTS cases reported as mild to moderate intensity and occurred early
None stopped treatment medication as a result of CTS.
CTS was significantly increased for women who used ptior HRT or received prior chemotherapy
Participants 60 years of age or older at entry at lower risk of CTS compared with counterparts

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