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Sisler IY et al. – Total body irradiation (TBI)–based conditioning regimens for pediatric patients with acute myelogenous leukemia (AML) beyond first complete remission (CR1) are controversial. Because the long–term morbidity of busulfan–based regimens appears to be lower, determining efficacy is critical. The study provides no evidence of an advantage to using TBI in children with AML beyond CR1. A prospective, randomized study is needed to confirm these results.


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