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Hepatic Safety of Voriconazole after Allogeneic Hematopoietic Stem Cell Transplantation
Biology of Blood and Marrow Transplantation, 09/18/09
Amigues I et al. – Voriconazole is increasingly used in allogeneic hematopoietic stem cell transplantation (HSCT) for prophylaxis and treatment of fungal infections. Hepatic dysfunction is common in patients undergoing HSCT and may impact the clinical decision to institute voriconazole. In general, the hepatic dysfunction was mild and reversible. Voriconazole therapy, with monitoring, appears to be reasonably safe for use in HSCT recipients at high risk for invasive fungal infections.
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