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Polymorphism of Interleukin-23 Receptor Gene But Not of NOD2/CARD15 Is Associated with Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation in Children
Biology of Blood and Marrow Transplantation, 09/18/09

Gruhn B et al. – Graft–versus–host disease (GVHD) is a major cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). The findings could be particularly relevant for children with inborn metabolic or immunologic disorders who do not benefit from a graft–versus–tumor effect, and therefore, selection of a donor with the IL23R polymorphism might be beneficial.

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