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Concordant DNA Methylation in Synchronous Colorectal Carcinomas
Cancer Prevention Research, 09/16/09
Konishi K et al. – Synchronous colorectal tumors of the same site are highly concordant for methylation of multiple genes, BRAF mutations, and a cribriform glandular configuration, all consistent with a patient–specific predisposition to particular subtypes of colorectal cancers. Screening for and secondary prevention of colon cancer should take this fact into account.
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Today in Basic Science/Genetics...keeping you current
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