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See Latest ArticlesA phase I/II study of the safety and efficacy of the addition of sirolimus to tacrolimus/methotrexate graft versus host disease prophylaxis after allogeneic haematopoietic cell transplantation in paediatric acute lymphoblastic leukaemia (ALL)
British Journal of Haematology, 09/15/09
Pulsipher MA et al. – Sirolimus-based GVHD prophylaxis can be given safely in this population and early survival results are promising. A phase III trial to test whether sirolimus decreases relapse and improves outcome after transplantation for ALL is ongoing.
Methods- Study cohort included 18 patients in high-risk (HR) first complete remission (CR1)
- 16 in HR CR2
- 17 in intermediate risk (IR) CR2
- 12 in CR3+
- 2-year event-free survival (EFS) of the cohort was 66%
- EFS of risk groups was 74%, 81%, 44% and 46% for CR1, IR CR2, HR CR2 and CR3+ patients
- Cumulative incidence of acute GVHD grade II–IV and III–IV was 38% and 21% respectively, while the cumulative incidence of chronic GVHD was 32%
- Cumulative incidence of transplant-related mortality and relapse was 10% and 25% respectively
- Cumulative incidence of chronic GVHD was 32%
- Significant toxicities included veno-occlusive disease (seven patients)
- Transplant-associated microangiopathy (three patients)
- Idiopathic pneumonitis (one patient)
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Today in BMT/SCT...keeping you current
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Nonmyeloablative and Reduced-Intensity Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation: A Clinical Review
American Journal of Clinical Oncology, 12/07/09
Performing allogeneic and autologous hematopoietic SCT in the outpatient setting: effects on infectious complications and early transplant outcomes
Bone Marrow Transplantation, 12/03/09
Dermatologic manifestations of hematopoietic stem cell transplantation: understanding and management
Expert Review of Dermatology, 12/03/09
Today in Leukemia/Lymphoma...keeping you current
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Impact of dexamethasone responsiveness on long term outcome in patients with newly diagnosed multiple myeloma
British Journal of Haematology, 12/08/09
Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia
Blood, 12/08/09
Today in Pharmacology/Therapy...keeping you current
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Definitive chemoradiation therapy with capecitabine in locally advanced pancreatic cancer
Anti-Cancer Drugs, 12/08/09
Is gemcitabine an option in BCG-refractory nonmuscle-invasive bladder cancer? A single-arm prospective trial
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Impact of dexamethasone responsiveness on long term outcome in patients with newly diagnosed multiple myeloma
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