Oncology Medical News about head and neck cancer; alcohol; smoking

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Total Exposure and Exposure Rate Effects for Alcohol and Smoking and Risk of Head and Neck Cancer: A Pooled Analysis of Case-Control Studies
American Journal of Epidemiology, 09/11/09

Lubin JH et al. – Although cigarette smoking and alcohol consumption increase risk for head and neck cancers, there have been few attempts to model risks quantitatively and to formally evaluate cancer site–specific risks.

Methods

The authors pooled data from 15 case–control studies and modeled the excess odds ratio (EOR) to assess risk by total exposure (pack–years and drink–years) and its modification by exposure rate (cigarettes/day and drinks/day).
The smoking analysis included 1,761 laryngeal, 2,453 pharyngeal, and 1,990 oral cavity cancers, and the alcohol analysis included 2,551 laryngeal, 3,693 pharyngeal, and 3,116 oval cavity cancers, with over 8,000 controls.

Results

Above 15 cigarettes/day, the EOR/pack–year decreased with increasing cigarettes/day, suggesting that greater cigarettes/day for a shorter duration was less deleterious than fewer cigarettes/day for a longer duration.
Estimates of EOR/pack–year were homogeneous across sites, while the effects of cigarettes/day varied, indicating that the greater laryngeal cancer risk derived from differential cigarettes/day effects and not pack–years.
EOR/drink–year estimates increased through 10 drinks/day, suggesting that greater drinks/day for a shorter duration was more deleterious than fewer drinks/day for a longer duration. Above 10 drinks/day, data were limited.
EOR/drink–year estimates varied by site, while drinks/day effects were homogeneous, indicating that the greater pharyngeal/oral cavity cancer risk with alcohol consumption derived from the differential effects of drink–years and not drinks/day.

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Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk
International Journal of Epidemiology, 10/08/09 Relevance Score: 84%

Planned neck dissection following primary chemoradiation for advanced-stage head and neck cancer
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Extracts from The Cochrane Library: Erythropoietin as an adjuvant treatment with (chemo) radiation therapy for head and neck cancer
Otolaryngology Head and Neck Surgery, 10/12/09 Relevance Score: 83%

Clinical Features and Short-Term Outcome of Critically Ill Patients With Head and Neck Cancer in the Medical Intensive Care Unit
American Journal of Clinical Oncology, 10/07/09 Relevance Score: 83%

Sheddase Activity of Tumor Necrosis Factor-alpha Converting Enzyme Is Increased and Prognostically Valuable in Head and Neck Cancer
Cancer Epidemiology, Biomarkers & Prevention, 10/27/09 Relevance Score: 82%