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See Latest ArticlesAntibody response to polysaccharide conjugate vaccines after nonmyeloablative allogeneic stem cell transplantation
Biology of Blood and Marrow Transplantation, 09/15/09
Meerveld-Eggink A et al. – Vaccination of patients at a median of 15 months post-allo-RIST leads to significant rise in concentrations of pneumococcal, Hib, and TT antibodies in the majority of patients.
Methods- Reconstitution of humoral immunity after allo-RIST is determined by measuring the vaccination-induced antibody response against Streptococcus pneumoniae, Haemophilus influenzae type b (Hib), and tetanus toxoid (TT) 1 year posttransplantation
- Patients who underwent allo-RIST vaccinated according to schedule starting at 12 months following transplantation with conjugated vaccines against S. pneumoniae, Hib, and TT
- Pre- and post-vaccination sera were available for all 26 patients
- Required to be off immunosuppression at the time of vaccination
- 9 of the 26 patients did not start vaccination at 12 months post-stem cell transplantation but at median range of 15 posttransplantation
- Except for pneumococcal serotype 6B, more than 73% of the patients developed antibody levels ≥ 0.35μ g/mL for all pneumococcal serotypes included in the vaccine
- For Hib and TT, protective antibody levels were found in 77% and 96% of the patients, respectively
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