Oncology Medical News about pentostatin

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Evaluation of pentostatin in corticosteroid-refractory chronic graft-versus-host disease in children: a Pediatric Blood and Marrow Transplant Consortium study
Blood, 09/18/09

Jacobsohn DA et al. – There is no standard therapy for steroid refractory chronic graft–versus–host disease (GVHD). This problem is particularly daunting in children with chronic GVHD, where the effects of the disease and its treatment may impair normal growth and development. Children are also particularly vulnerable to failure and/or toxicity of therapy; for example, joint contractures or joint damage may result in life–long disability. Pentostatin has activity in refractory chronic GVHD in children and future studies, including treatment of newly–diagnosed children with high–risk chronic GVHD, are warranted.

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