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See Latest ArticlesGerm-Line Mutations in Mismatch Repair Genes Associated with Prostate Cancer
Cancer Epidemiology, Biomarkers & Prevention, 09/14/09
Grindedal EM et al. – Genetic predisposition to prostate cancer includes multiple common variants with a low penetrance (single nucleotide polymorphisms) and rare variants with higher penetrance. The mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2 are associated with Lynch syndrome where colon and endometrial cancers are the predominant phenotypes. This study is the first to indicate that the MMR genes may be among the rare genetic variants that confer a high risk of prostate cancer when mutated.
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