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Reproductive factors and postmenopausal hormone use in relation to endometrial cancer risk in the Nurses Health Study cohort 1976-2004
International Journal of Cancer, 09/11/09
Karageorgi S et al. – The findings from this study underscore the importance of hormonal mechanisms in endometrial carcinogenesis.
Methods- The Nurses' Health Study, comprised of 121,700 nurses, to assess endogenous and exogenous hormones and risk of endometrial cancer
- Over 28 years of follow-up, 778 adenocarcinoma cases were diagnosed and 1,850,078 person-years were accumulated Results
- A late age at menarche decreased the risk independent of BMI
- A late age at menopause increased cancer risk
- An advanced age at last birth reduced the risk
- An inverse association with age at first birth and parity diminished after adjustment for age at last birth
- Compared with never users, an increased risk was observed among long-term (5 years) users of both E (RR = 7.67) and combined E + P (RR = 1.52)
- Normal-weight (BMI < 25) women had the highest risk following E or E+P use
Today in Endocrine Oncology...keeping you current
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Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer
Thyroid, 10/30/09Thyroid lymphoma and airway obstruction – is there a rationale for surgical management?
International Journal of Clinical Practice, 10/19/09Thyroid Cancer in Systemic Lupus Erythematosus: A Case-Control Study
Journal of Clinical Endocrinology and Metabolism, 11/12/09Today in Gynecologic Oncology...keeping you current
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Ovarian cancer screening and early detection
Women's Health, 11/04/09Dose-dense paclitaxel once a week in combination with carboplatin every 3 weeks for advanced ovarian cancer: A phase 3, open-label, randomised controlled trial
The Lancet, 11/23/09Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia
New England Journal of Medicine, 11/06/09
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