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Bcl-2 Modulation to Activate Apoptosis in Prostate Cancer
Molecular Cancer Research, 09/15/09
Bray K et al. – In human prostate cancer tissue, examined using a novel tumor explant system designated Tumor Tissue Assessment for Response to Chemotherapy, combination chemotherapy promoted efficient apoptosis. Thus, rational targeting of both the Bcl–2 and Mcl–1 mechanisms of apoptosis resistance may be therapeutically advantageous for advanced prostate cancer.
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