Oncology Medical News about advanced ovarian cancer;CT scan-based and clinical evlauation;optimal cytoreduction

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Role of CT scan-based and clinical evaluation in the preoperative prediction of optimal cytoreduction in advanced ovarian cancer: a prospective trial
British Journal of Cancer, 09/10/09

Ferrandina G et al. – Computed scan still represents a valid tool to predict ovarian cancer optimal cytoreduction; the predictive ability of a CT scan-based model is improved by integrating ECOG-PS data.

Methods

Prospective study
Pre-operative CT scans were performed with a high-speed scanner
All patients underwent standard laparotomy, and maximal surgical effort was attempted
The following CT parameters were used: peritoneal thickening, peritoneal implants >2 cm, bowel mesentery involvement, omental cake, pelvic sidewall involvement and/or hydroureter, suprarenal aortic lymph nodes >1 cm, infrarenal aortic lymph nodes >2 cm, superficial liver metastases >2 cm and/or intraparenchimal liver metastases any size, large volume ascites (>500 ml)
Radiographic and clinical features exhibiting a specificity >75%, a positive and negative predictive value >50%, an accuracy >60% in predicting surgical outcome were assigned a point value of 2

Results

The PI scores ranged from 0 to 6, and from 0 to 8, in Model 1 (including only radiographic parameters) and in Model 2 (including radiographic and clinical data)
The AUC was 0.78+0.035 in Model 1, and 0.81+0.031 in Model 2
Therefore, the addition of ECOG-PS data led to the improvement of the diagnostic performances

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