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See Latest ArticlesCarcinoma of the nasopharynx in young patients: a single institution experience
Clinical Oncology, 09/10/09
Shen C et al. – A high systemic failure remains a major obstacle to cure young NPC patients.
Methods- 42 NPC patients aged ?20 years (median age, 16 years)
- 14 were stage II, 21 stage III, and 7stage IV
- 17patients received radiotherapy alone and 25 had cisplatin-based chemotherapy additionally
- The radiation dose to the primary tumour and involved nodes was 64–74Gy
- After a median follow-up of 60 months, the 5-year locoregional control, overall survival and disease-free survival rates were 87, 79 and 73%, respectively
- More than 50% of the relapses (6/11) were distant metastases
- Patients with N0-1 had a lower distant metastasis rate compared with patients with N2-3, and the TNM stage grouping was found to be a marginally important prognostic factor for disease-free survival
- The addition of chemotherapy failed to be of therapeutic value
- Acute and chronic toxicities were limited, consisting primarily of mucositis and xerostomia
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Today in Head and Neck...keeping you current
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Today in Pediatric Heme/Oncology...keeping you current
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