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Kwok WK et al. – Invasion chamber assay showed that TIG1 knockdown in HK1–EBV cells resulted in significant enhancement of invasive capacity of HK1–EBV cells (P = 0.006). HK1 cells were not invasive, regardless of TIG1 status. These findings suggest that TIG1 may play a role in cellular proliferation and invasion in NPC cells and that its function may be dependent on the EBV status.

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