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Effect of artesunate on inhibiting proliferation and inducing apoptosis of SP2/0 myeloma cells through affecting NFkappaB p65
International Journal of Hematology, 09/15/09

Li S et al. – Artesunate treatment decreased the level of NFkappaB p65 protein in the nucleus, while increased the level of IkappaBalpha protein in the cytoplasm. The present result is the first report to show that artesunate may be useful in the treatment of MM.

Exclusive Author Commentary
Ling Pan, 09/17/09

Introduction Multiple myeloma (MM) is a lethal malignant plasmacyte disease. The efficacy of traditional chemotherapy strategy was not satisfactory. The median survival period of the patients was about 3 years. During the past decade, higher rates of complete response (CR) and prolonged progression-free and overall survival have been seen with high-dose chemotherapy plus autologous stem-cell transplantation. However, the implementation of hematopoietic stem cell transplantation was restricted by multiple factors. Several new anti-MM drugs such as thalidomide, arsenic trioxide, etc, have being applied in the clinic in the recent years, but the efficacy remained unsatisfactory[1,2,3]. Some ongoing studies such as the combinaton of Pegylated liposomal doxorubicin (PLD) and botezomib are showing improvement in time-to-event outcomes[4,5], including TTP and OS, yet it was too expensive for Chinese patients. Based on the abnormality in signal transduction pathway in the pathogenesis of MM, it is of great importance to find targeted anti-MM bioactive components of low toxicity and high efficiency from traditional Chinese herbs. Artesunate, which was a semisynthetic artemisinin derivative,with the advantages of significant efficacy, light toxic and side effect, being very well tolerated by patients, was mainly used in the treatment of malaria initially [6]. Researches in recent years showed that it could inhibit DNA synthesis and cell growth in several tumor cell lines in vitro [7]. The molecular mechanisms of actionare not fully explored yet. Formation of carbon-centered free radicals has been suggested[8,9,10,11,12].There is no report, however, whether Artesunate is effective in the growth inhibition of MM cells. The present study is thus designed to investigate in vitro the effects of Artesunate on the proliferation inhibition and apoptosis induction in mouse myeloma cell line SP2/0 cells and try to explain its mechanism preliminarily. Materials and

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