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A panel of antibodies to determine site of origin and malignancy in smooth muscle tumors
Modern Pathology, 09/17/09
Lee C–H et al. – Diffuse p16 and p53 immunopositivity and high Ki–67 proliferation index, singly or in combination, yielded an overall sensitivity of 92% and specificity of 98% for distinguishing between gynecologic leiomyosarcomas and leiomyomas and can be used as indicators of malignancy for gynecologic smooth muscle tumors. Although ER positivity can be used to support the gynecologic origin of a leiomyosarcomas, nuclear WT1 immunostaining is of little use.
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Today in Basic Science/Genetics...keeping you current
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Tissue transglutaminase 2 as a biomarker of cervical intraepithelial neoplasia (CIN) and its relationship to p16INK4A and nuclear factor kappaB expression
Virchows Archiv, 12/04/09
MYCN/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN/c-MYC-activated tumors
Oncogene, 12/04/09
Overexpression of macrophage inhibitory cytokine-1 induces metastasis of human prostate cancer cells through the FAKāRhoA signaling pathway
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Today in Soft Tissue/Sarcoma...keeping you current
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Infantile Fibrosarcoma: Management Based on the European Experience
Journal of Clinical Oncology, 12/04/09
Transformation potential of bone marrow stromal cells into undifferentiated high-grade pleomorphic sarcoma
Journal of Cancer Research & Clinical Oncology, 12/04/09
Validation of potential therapeutic targets in alveolar soft part sarcoma: an immunohistochemical study utilizing tissue microarray
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