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See Latest ArticlesBiomarkers of apoptosis and survival in esophageal squamous cell carcinoma
BMC Cancer, 09/18/09
Takikita M et al. – Individual biomarkers in the apoptosis pathway do not appear to predict survival of patients with ESCC
Methods- 313 surgically-resected cases of ESCC specimens
- 7 genes in the FasL-Fas apoptotic pathway - FasL, Fas, FAS-associated death domain protein (FADD), phosphorylated-FADD, and caspase 8 and 10, and the antiapoptotic protein bcl-2 were evaluated
- Pathway integrity and relations to risk and clinical factors were evaluated, and the prognostic significance of each marker was determined
- 5 markers showed strong inter-marker correlations (r ? 0.28), including FasL, Fas, FADD, and caspases 8 and 10
- FasL and FADD also showed modest correlations with one or more cancer risk factors, but none of the markers was significantly associated with either tumor stage or lymph node metastasis, the only two clinical factors that predicted survival in these ESCC cases
- Multivariate-adjusted proportional hazard regression models showed no association between protein expression and risk of death for any of the seven markers examined.
Today in Basic Science/Genetics...keeping you current
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Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma
Clinical Cancer Research, 12/11/09
Analysis of VHL Gene Alterations and their Relationship to Clinical Parameters in Sporadic Conventional Renal Cell Carcinoma
Clinical Cancer Research, 12/11/09
Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation
British Journal of Haematology, 12/11/09
Today in GI Oncology...keeping you current
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Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin
The Journal of Pathology, 12/11/09
Extracapsular lymph node spread
Cancer, 12/11/09
Variations in gastric cancer care
Cancer, 12/11/09
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